Optimising Haemodynamics in Complex Stented Arteries

Grant number: LP150100233 | Funding period: 2016 - 2021

Completed

Abstract

This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.

Related publications (6)

Angiography-Based 4-Dimensional Superficial Wall Strain and Stress: A New Diagnostic Tool in the Catheterization Laboratory

X Wu, M Ono, H Kawashima, EKW Poon, R Torii, A Shahzad, C Gao, R Wang, P Barlis, C von Birgelen, JHC Reiber, CV Bourantas, S Tu, W Wijns, PW Serruys, Y Onuma

2021-01-01

A novel method for four-dimensional superficial wall strain and stress (4D-SWS) is derived from the arterial motion as pictured by..

A direct comparison of pulsatile and non-pulsatile rough-wall turbulent pipe flow

TO Jelly, RC Chin, SJ Illingworth, JP Monty, I Marusic, A Ooi

2020-07-25

Pulsatile rough-wall turbulent pipe flow is compared against its non-pulsatile counterpart using data obtained from direct numeric..

Numerical Study of Incomplete Stent Apposition Caused by Deploying Undersized Stent in Arteries With Elliptical Cross Sections

Bo Jiang, Vikas Thondapu, Eric KW Poon, Peter Barlis, Andrew SH Ooi

2019-05-01

Incomplete stent apposition (ISA) is one of the causes leading to poststent complications, which can be found when an undersized o..

Haemodynamic effects of incomplete stent apposition in curved coronary arteries

WX Chen, EKW Poon, V Thondapu, N Hutchins, P Barlis, A Ooi

2017-10-03

Incomplete stent apposition (ISA, also known as malapposition) is a complication that affects day-to-day coronary stenting procedu..

Computational fluid dynamics study of common stent models inside idealised curved coronary arteries

WX Chen, EKW Poon, N Hutchins, V Thondapu, P Barlis, A Ooi

2017-04-26

The haemodynamic behaviour of blood inside a coronary artery after stenting is greatly affected by individual stent features as we..

The Nidus for Possible Thrombus Formation: Insight From the Microenvironment of Bioresorbable Vascular Scaffold

E Tenekecioglu, EKW Poon, C Collet, V Thondapu, R Torii, CV Bourantas, Y Zeng, Y Onuma, ASH Ooi, PW Serruys, P Barlis

2016-10-24

University of Melbourne Researchers